2024
Intercellular mitochondrial transfer from human neural stem cells and brain tumour initiating cells into neighbouring astrocytes
Cells 13(3), 204
Regenerative medicine · Abu Dhabi
We form living tissue.
From a preserved, renewable cell source to organoids that grow, fold and function. The genesis layer of regenerative medicine.
The name is the method.
01 / Name & story
تكوين الأنسجة
takwīn al-ansija
tissue formation
Formation. Genesis. The act of bringing into being – the same root, k-w-n, that gives kawn, the cosmos, and ʿilm al-takwīn, embryology.
TAKWYN forms living tissue from cells: from a preserved, renewable starting point to structures that grow, fold and function. We work at the layer below therapy, where tissue is made.
Building in Abu Dhabi, on governed access to biological material, genomic data and GMP pathways.
Four pillars, one starting point.
02 / Platform
01
iPSC Reprogramming
Induced pluripotent stem cell lines derived from preserved biological material, then expanded, characterised and cryobanked. One donor, one genome, one line, many tissues.
Donor-derived linesQC & karyotypeCryobanking
02
Brain Organoids
Standardised cortical organoids for neural modelling today, with neural repair as the long-horizon goal. Built for genome-linked cohorts rather than single lines.
NeurodegenerationNeurodevelopmentCNS discovery
03
Liver Organoids
Patient-matched hepatic tissue for metabolism and toxicity work, moving toward functional cell therapy. Paired with the neural line from the same donor.
MetabolismToxicologyPatient-matched
04
Mitochondrial Therapy
Augmentation and transplantation of healthy mitochondria: a mechanism central to ageing, neurodegeneration and metabolic disease, and a route to restoring cellular energy.
Transfer & transplantRespiration assaysAgeing biology
The long horizon
Neural modelling today. Neural repair tomorrow.
From preserved cells to living tissue.
03 / Translational pathway
Preserve
Governed biological material with linked genomic and clinical data.
Reprogram
Donor-derived iPSC lines, characterised and banked.
Engineer
Bioreactor and scaffold conditions tuned for reproducibility.
Differentiate
Brain and liver organoids from the same genome.
Translate
Phenotyping, data integration and a route to therapy.
One donor
Preserved material
One genome
Linked sequence data
One iPSC line
Renewable, banked
Many organoids
Brain · liver · beyond
Genomes are read. We make them functional.
04 / Infrastructure
The region has invested at national scale in reading the genome. The layer that is still missing is functional: living human tissue in which a genome can be tested, not only described.
TAKWYN is built around that layer, in Abu Dhabi, close to the biological material, the data and the regulatory pathway rather than at a distance from them.
Material
Governed access to preserved biological material under consented, auditable use.
Data
Genomic and clinical metadata held and processed in-country.
Facility
Organoid suite designed for reproducibility, QC and cryobanking at scale.
Pathway
A route from research-grade tissue toward GMP and clinical translation.
Built on published work.
05 / Science
2018
Characterisation of brain tumour initiating cells from an animal model of CNS primitive neuroectodermal tumours
Oncotarget 9(17)
2015
A mouse model of radial glial cell-derived primitive neuroectodermal tumours
PLOS ONE 10(3)
2014
Onset of rosette formation during spontaneous neural differentiation of hESC and hiPSC colonies
Gene 534(2)
Selected work by the founding scientific team · full list on the science page
06 / Contact
Partnerships, programmes and investment.
For research collaborations, pharma partnerships and investor materials.